North American Triple Reassortant and Eurasian H1N1 Swine Influenza Viruses Do Not Readily Reassort to Generate a 2009 Pandemic H1N1-Like Virus
Identifieur interne : 000696 ( Main/Exploration ); précédent : 000695; suivant : 000697North American Triple Reassortant and Eurasian H1N1 Swine Influenza Viruses Do Not Readily Reassort to Generate a 2009 Pandemic H1N1-Like Virus
Auteurs : Wenjun Ma ; Qinfang Liu ; Chuanling Qiao ; Gustavo Del Real ; Adolfo García-Sastre ; Richard J. Webby ; Jürgen A. RichtSource :
- mBio [ 2150-7511 ] ; 2014.
Abstract
The 2009 pandemic H1N1 virus (pH1N1) was derived through reassortment of North American triple reassortant and Eurasian avian-like swine influenza viruses (SIVs). To date, when, how and where the pH1N1 arose is not understood. To investigate viral reassortment, we coinfected cell cultures and a group of pigs with or without preexisting immunity with a Eurasian H1N1 virus, A/Swine/Spain/53207/2004 (SP04), and a North American triple reassortant H1N1 virus, A/Swine/Kansas/77778/2007 (KS07). The infected pigs were cohoused with one or two groups of contact animals to investigate viral transmission. In coinfected MDCK or PK15 continuous cell lines with KS07 and SP04 viruses, more than 20 different reassortant viruses were found. In pigs without or with preexisting immunity (immunized with commercial inactivated swine influenza vaccines) and coinfected with both viruses, six or seven reassortant viruses, as well as the parental viruses, were identified in bronchoalveolar lavage fluid samples from the lungs. Interestingly, only one or two viruses transmitted to and were detected in contact animals. No reassortant containing a gene constellation similar to that of pH1N1 virus was found in either coinfected cells or pigs, indicating that the reassortment event that resulted in the generation of this virus is a rare event that likely involved specific viral strains and/or a favorable, not-yet-understood environment.
Url:
DOI: 10.1128/mBio.00919-13
PubMed: 24618255
PubMed Central: 3952159
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">North American Triple Reassortant and Eurasian H1N1 Swine Influenza Viruses Do Not Readily Reassort to Generate a 2009 Pandemic H1N1-Like Virus</title><author><name sortKey="Ma, Wenjun" sort="Ma, Wenjun" uniqKey="Ma W" first="Wenjun" last="Ma">Wenjun Ma</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Liu, Qinfang" sort="Liu, Qinfang" uniqKey="Liu Q" first="Qinfang" last="Liu">Qinfang Liu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Qiao, Chuanling" sort="Qiao, Chuanling" uniqKey="Qiao C" first="Chuanling" last="Qiao">Chuanling Qiao</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Del Real, Gustavo" sort="Del Real, Gustavo" uniqKey="Del Real G" first="Gustavo" last="Del Real">Gustavo Del Real</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name></author><author><name sortKey="Webby, Richard J" sort="Webby, Richard J" uniqKey="Webby R" first="Richard J." last="Webby">Richard J. Webby</name><affiliation><nlm:aff id="aff6"></nlm:aff></affiliation></author><author><name sortKey="Richt, Jurgen A" sort="Richt, Jurgen A" uniqKey="Richt J" first="Jürgen A." last="Richt">Jürgen A. 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Webby</name><affiliation><nlm:aff id="aff6"></nlm:aff></affiliation></author><author><name sortKey="Richt, Jurgen A" sort="Richt, Jurgen A" uniqKey="Richt J" first="Jürgen A." last="Richt">Jürgen A. Richt</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">mBio</title><idno type="eISSN">2150-7511</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><p>The 2009 pandemic H1N1 virus (pH1N1) was derived through reassortment of North American triple reassortant and Eurasian avian-like swine influenza viruses (SIVs). To date, when, how and where the pH1N1 arose is not understood. To investigate viral reassortment, we coinfected cell cultures and a group of pigs with or without preexisting immunity with a Eurasian H1N1 virus, A/Swine/Spain/53207/2004 (SP04), and a North American triple reassortant H1N1 virus, A/Swine/Kansas/77778/2007 (KS07). The infected pigs were cohoused with one or two groups of contact animals to investigate viral transmission. In coinfected MDCK or PK15 continuous cell lines with KS07 and SP04 viruses, more than 20 different reassortant viruses were found. In pigs without or with preexisting immunity (immunized with commercial inactivated swine influenza vaccines) and coinfected with both viruses, six or seven reassortant viruses, as well as the parental viruses, were identified in bronchoalveolar lavage fluid samples from the lungs. Interestingly, only one or two viruses transmitted to and were detected in contact animals. No reassortant containing a gene constellation similar to that of pH1N1 virus was found in either coinfected cells or pigs, indicating that the reassortment event that resulted in the generation of this virus is a rare event that likely involved specific viral strains and/or a favorable, not-yet-understood environment.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Tong, S" uniqKey="Tong S">S Tong</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Rivailler, P" uniqKey="Rivailler P">P Rivailler</name></author><author><name sortKey="Conrardy, C" uniqKey="Conrardy C">C Conrardy</name></author><author><name sortKey="Castillo, Da" uniqKey="Castillo D">DA Castillo</name></author><author><name sortKey="Chen, Lm" uniqKey="Chen L">LM Chen</name></author><author><name sortKey="Recuenco, S" uniqKey="Recuenco S">S Recuenco</name></author><author><name 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Woods</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author><author><name sortKey="Webby, Rj" uniqKey="Webby R">RJ Webby</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Del Real, Gustavo" sort="Del Real, Gustavo" uniqKey="Del Real G" first="Gustavo" last="Del Real">Gustavo Del Real</name><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name><name sortKey="Liu, Qinfang" sort="Liu, Qinfang" uniqKey="Liu Q" first="Qinfang" last="Liu">Qinfang Liu</name><name sortKey="Ma, Wenjun" sort="Ma, Wenjun" uniqKey="Ma W" first="Wenjun" last="Ma">Wenjun Ma</name><name sortKey="Qiao, Chuanling" sort="Qiao, Chuanling" uniqKey="Qiao C" first="Chuanling" last="Qiao">Chuanling Qiao</name><name sortKey="Richt, Jurgen A" sort="Richt, Jurgen A" uniqKey="Richt J" first="Jürgen A." last="Richt">Jürgen A. 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